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The researchers weren't sure why

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Symptoms of B12 deficiency include exhaustion no matter how much you sleep, muscle weakness and frequent cramping, constipation, loss of appetite and unexplained weight loss, numbness or tingling in the hands and feet, depression, and problems with memory and focus

Fatigue can come from sleep, thyroid status, anemia, mood, medications, nutrition, or chronic disease

5-Amino-1MQ 5-Amino-1MQ works by inhibiting nicotinamide N-methyltransferase (NNMT) , an enzyme that regulates NAD metabolism and influences fat storage

doi:10.1002/mds.20124