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Os mais frequentes incluem nuseas, sensao de enfartamento, obstipao, diarreia ou refluxo gstrico, sobretudo nas primeiras semanas de tratamento, geralmente transitrios e controlveis com ajustes da dose

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While the GLP-1R is well-known to stimulate cAMP production leading to Protein Kinase A (PKA) and Exchange Protein Activated by cyclic AMP 2 (Epac2) activation, there is a lack of understanding of the molecular mechanisms linking GLP-1R signalling with mitochondrial and -cell functional adaptation

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Effects of GLP-1 receptor agonists on myokine levels and pro-inflammatory cytokines in patients with type 2 diabetes mellitus

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