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Ten patients with obesity and type 2 diabetes received weekly subcutaneous semaglutide, escalated from 0.25 mg to 1 mg over 4 weeks and maintained for 8 more weeks (12 weeks total)

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While no specific guidelines exist for MC4R -deficient patients, extrapolating from osteoporosis management principles suggests that baseline dual-energy X-ray absorptiometry (DXA) assessment may be reasonable in individuals with additional fracture risk factors or those anticipating substantial and sustained weight loss [72]