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Special Precautions Administration of high doses of the oral formulations of levocarnitine for long periods of time is not recommended in patients with severely compromised renal function or in ESRD patients on dialysis due to the fact that major metabolites formed following oral administration trimethylamine (TMA) and trimethylamine-N-oxide (TMAO) will accumulate since they can not be efficiently removed by the kidneys

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The gradual approach allows the body to adjust safely while improving the effectiveness of appetite control

[7] In studies conducted by three independent laboratories by the US National Institute on Aging's intervention testing programme, acarbose was shown to extend the lifespan of female mice by 5% and of male mice by 22%

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