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Confounding factors and mitigation strategies in the study of acylcarnitine biomarkers in DKD Core confounding factors The interpretation of acylcarnitine levels is influenced by multiple confounding factors that must be carefully considered in both research design and clinical practice

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It helps regulate metabolism by influencing how the body uses carbohydrates, fats, and proteins for energy

Indirect effects on blood pressure and body weight may also play a role

FIGURE 5 3.5 Glutathione Reductase No significant variation was observed in groups 1 to 3 for the GR response

However, when metformin proves insufficient, patients often transition to second-line therapies like GLP-1 RAs