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Data in weight loss Most of the existing empirical data on weight loss with GLP-1 agonists come from studies of individuals who are overweight or obese, with or without type 2 diabetes, rather than from studies using these agents to counteract iatrogenic weight gain

This means that the FDA has not verified their safety, effectiveness, or quality

Extended periods at elevated temperatures, however, accelerate peptide degradation through hydrolysis and oxidation reactions

Safety of administration along with any other weight loss supplement has not yet been official

Germline mutations in BRCA1/2 hamper the DNA repairing ability, progressing to genomic instability and malignant transformation

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