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Excessive ROS can damage cellular DNA, proteins, and lipids, resulting in cellular dysfunction ( Figure 1

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We then discuss the favorable effect of HGF in promoting neuron survival in the context of brain injury and in neurodegenerative disorders, pointing out its pro-angiogenic, anti-fibrotic, anti-inflammatory, immune-modulatory, and neuro-regenerative properties

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Thus, we performed an in vitro palmitoylation assay by mixing highly purified recombinant DHHC9 and GCP16, which have been reported to constitute a PAT 13,14 , with GLUT1 in the presence of palmitoyl alkyne-CoA as the palmitate donor (Fig