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Yun Fan et al

Conditions such as multiple sclerosis (MS), autoimmune encephalitis, and pediatric neuropsychiatric syndromes like PANS and PANDAS are characterized by an immune system that mistakenly targets the brain, leading to symptoms ranging from brain fog and fatigue to seizures, cognitive decline, and severe behavioral changes

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1 Aromatase inhibitors are thought to be most helpful in men with a low testosterone and relatively high estrogen levels, and are sometimes used in conjunction with clomiphene citrate

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They observed that the binding sites were specifically associated with the genes controlling immune functions and furthermore, the binding positively regulated the expression of these genes