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Korea Drug Development Fund funded by Ministry of Science and ICT, Ministry of Trade, Industry, and Energy, and Ministry of Health and Welfare (HN21C1076)

- Evidence: Meta-analysis: 91 placebo-controlled trials, 107,910 patients Retrospective cohort study: 2.2M users via FDA Sentinel System No signal for SI/B, anxiety, depression, irritability, or psychosis - Action: FDA requesting removal of SI/B warning from Wegovy, Saxenda, and Zepbound labeling

PlGF: A Multitasking Cytokine with Disease-Restricted Activity

Segment Analysis By Drug: Ozempic Dominance Faces Dual-Agonist Challenge The GLP-1 diabetes drugs market size for brand-level competition shows Ozempic at USD 11.36 billion revenue in 2025, translating to a 31.88% GLP-1 diabetes drugs market share

Joseph Chandy estimates that 1 in 10 people experience this phenomenon

Some reports describe tolerated doses with no immediate side effects but do not assess efficacy