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Pancreatitis Risk: When Tirzepatide Requires Caution Patients with a personal history of acute pancreatitis should use tirzepatide only under close medical supervision because GLP-1 agonists carry a potential increased risk of pancreatitis recurrence

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The absence of comprehensive safety and toxicological evaluations further limits the scope of clinical applicability

doi: 10.1096/fj.05-4985fje

In the SURPASS clinical trials for type 2 diabetes, nausea occurred in 1222% of patients, diarrhea in 1216%, and vomiting in 59%, with incidence varying by dose