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It was shown that in some cells direct inhibition of glutamate cysteine ligase (GCL) by BSO may upregulate factors involved in other antioxidative pathways (e.g

DTT was the most potent, blocking AX effect at equimolar ratios ( Figure 6A ), as expected from its higher reduction potential and the presence of two thiols in the molecule

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Notably, docking scores against NF-B and COX-2 are high for curcumin from Curcuma longa and quercetin-like flavonoids in agreement with their anti-inflammatory actions

Membranes were blocked in 3% fat-free milk for 2 h at room temperature, then incubated overnight at 4 C in primary antibodies (Ku70 (1:1000) Cell Signaling Technologies D10A7, Actin (1:5000) Novus Biologicals nb600-535, Pol (1:1000) Abcam ab26343) diluted in 3% BSA