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Also promising is the usage of these imaging modalities in the selection of patients that may benefit from an extended time window of intravenous thrombolysis (176) and in the early detection of patients that may develop severe stroke complications such as HT, which would be key in the specific guided treatment of AIS patients avoiding, therefore, poorer prognosis and adverse clinical developments (154)

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Notably, MSNs-ss-SA treatment led to the highest enhancement, with callose deposition reaching approximately 1.3-fold greater than that of the control (Fig