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When it became clear over a decade ago that tamoxifen is a prodrug and is converted to the major active metabolite (endoxifen) primarily by the enzyme CYP2D6, papers began to appear describing reduced tamoxifen efficacy in breast cancer patients with reduced CYP2D6 activity due either to genotype or drugs that inhibit CYP2D6

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Rare cases of hypersensitivity reactions, sometimes severe (e.g., anaphylactic reactions, angioedema, bronchospasm, shortness of breath, hypotension, laryngeal edema, stridor) have also been reported

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doi: 10.1111/J.1582-4934.2006.TB00407.X 169 VistoliGde MaddisDCipakAZarkovicNCariniMAldiniG