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doi: 10.3389/fcell.2021.683609 Received 21 March 2021 Accepted 30 April 2021 Published 09 June 2021 Volume 9 - 2021 Edited by Jiri Novotny, Charles University, Czechia Reviewed by Flavio Maina, Aix-Marseille Universit, France

Notably, 25% of participants had low serotonin levels, which correlated with both sleep difficulties and depressive symptoms, suggesting that serotonin deficiency plays a key role in insomnia

overwhelming this clearance pathway leads to hepatic accumulation resembling the pathology of Wilsons disease

What patients notice first depends on their individual baseline

Epidural steroid injections provide faster symptom relief but do not promote tissue repair

genetic association studies [6]