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Intramuscular (IM) injections into the gluteal muscles are commonly used for medications that require deep muscle absorption
PMID: 29155147): 5-Amino-1MQ showed NNMT selectivity with IC50 of 1.2 microM Reduced body weight and white adipose mass in diet-induced obese mice over 11 days No effect on food intake, suggesting metabolic rather than appetitive mechanism Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice , published in Scientific Reports (Dimet-Wiley AL et al., 2024
The good news is that any side effects tend to be mild and temporary, with some people experiencing no side effects at all
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A study in the Journal of the American Geriatrics Society showed benefits
The goal is not to force the body into losing fat through external manipulation but to restore metabolic function that allows healthy body composition to occur naturally
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