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GLP-1R, as its receptor, can bind to GLP-1 to exert its growth factor effects

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These effects help prevent bone metabolic diseases such as osteoporosis and promote fracture healing and repair of other bone injuries

Why Fiber Is Crucial When You're Taking a GLP-1 Drug Along with other forms of gastrointestinal distress, constipation is another common side effect of GLP-1 drugs

Regarding receptor-specific interactions, the retatrutideGLP-1R complex displays three salt bridges (D9 P R 7.35b , D15 P R299 ECL2 and K17 P E 1.33b ), with the first two also present in the retatrutideGIPR complex, while the last one is absent in GIPR due to the positively charged R131 1.33b

10.12758/mda.2021.08 10 BezinJ.GouverneurA.PnichonM.MathieuC.GarrelR.Hillaire-BuysD.et al (2023)