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18 Table 4 Time to Improvement of Abnormalities in Vitamin B12 Deficiency After Initiation of Treatment A 2005 Cochrane review involving 108 patients with vitamin B 12 deficiency found that high-dose oral replacement (1 mg to 2 mg per day) was as effective as parenteral administration for correcting anemia and neurologic symptoms
Animal toxicology studies have generally shown low acute toxicity at studied doses, but long-term safety data in humans are absent
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This disease was first described in 1971 by Nagashima, a Japanese dermatologist (234, 235)
10.1111/j.1526-4610.2006.00337.x Headache J
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