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During the mitochondrial life cycle, mitochondrial fission and fusion can regulate both the equilibrium of mitochondrial dynamics and mitochondrial biogenesis

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doi:10.1080/07420528.2020.1727918

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Although patients neutrophils exhibit a low reduced glutathione (GSH)/oxidised glutathione (GSSG) ratio and a higher total Nrf2 level, the DNA-binding activity of nuclear Nrf2 remained unchanged relative to healthy controls and had reduced expression of glutamate cysteine ligase catalytic (GCLC), and modifier (GCLM) subunit mRNAs, compared to periodontally healthy subjects neutrophils