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That usually means a BMI above 30, or above 27 with a comorbidity such as hypertension, diabetes, or sleep apnea, plus documentation of prior weight-loss interventions that did not work

These are short peptide chains that appear to carry tissue-specific signaling functions and can influence gene expression in targeted organs

doi: 10.1038/s41590-024-01985-9 95 WangRLiCChengZLiMShiJZhangZet al