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If degradation has reduced potency by 20 percent, your actual dose is 20 percent lower than intended

Zhang, S.-L

Why the IV-to-subcutaneous gap is not a technicality For many peptides, moving from IV to subcutaneous changes the pharmacokinetics modestly a slower rise, a lower peak, decent bioavailability

Levy F, Hay DA, McStephen M, Wood C, Waldman I (1997)

Friden M, Gupta A, Antonsson M, Bredberg U, Hammarlund-Udenaes M

doi: 10.3389/fped.2014.00066 Received 09 May 2014 Accepted 09 June 2014 Published 27 June 2014 Volume 2 - 2014 Edited by Roberto Canitano, University Hospital of Siena, Italy Reviewed by Andrew Walter Zimmerman, Harvard Medical School, USA