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Importantly, body weight reduction is significantly larger for patients administered with exenatide ER in comparison to administered sitagliptin (2.3 vs

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GLP-1RA could not only facilitate the M2 polarization of microglia through both direct and indirect pathways, but also modulate the quantity and function of T cell subtypes, including CD4, CD8, and regulatory T cells, resulting into the inhibition of inflammatory responses and the promotion of neuronal regeneration through interleukin-10 secretion

Apoptosis is regulated by the balance between pro-apoptotic proteins (Bax, Bak) and anti-apoptotic proteins (Bcl-2), with p53 promoting pro-apoptotic gene expression [31]

They support nerve cell function, which is vital for focus, memory, and overall cognitive performance

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