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8 Moreover, one should consider the fact that different GLP-1 RAs were used across the studies, with different chemical structures, durations of action and weight-lowering effects, which may impact their efficacy

Astrup A, Madsbad S, Breum L, Jensen TJ, Kroustrup JP, Larsen TM Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial

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Retatrutide is an investigational triple agonist activating GLP-1, GIP, and glucagon receptors simultaneously

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The approach depends entirely on the cause