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In addition, there were no significant differences in the levels of serum and CSF interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), resistin plasminogen activator inhibitor-1 (PAI-1), tissue necrosis factor- (TNF-), and hepatocyte growth factor (25)

Key GLP agonist companies such as Sciwind, Boehringer Ingelheim, Merck, Eccogene, Suzhou, Regor Pharmaceuticals, Eli Lilly and Company, Neuraly, Carmot Therapeutics, Viking Therapeutics, Biolexis Therapeutics and others are evaluating new GLP agonist drugs to improve the treatment landscape

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These cellular damages lead to release of pro-inflammatory mediators such as ATP, extracellular vesicles, and chemokines, subsequently reinforcing the inflammatory process and leading to the development of fibrosis

Activation of STAT signaling pathways and induction of suppressors of cytokine signaling (SOCS) proteins in mammalian lens by growth factors