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The therapy comes with a boxed warning for cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome

Heavier individuals with more adipose tissue often benefit from doses at the higher end of the standard range (450-500mcg)

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More serous B12 deficiencies have the potential to impair heart and neurological function, leading to a wide range of serous symptoms, including but not limited to tinnitus, severe joint pain, memory problems, depression, anxiety, poor muscle function, ataxia, and changes in reflexes

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