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Further optimization of GLP-1 analogues to permit once-weekly time action led to the discovery of Fc protracted dulaglutide and the fatty diacid acylated semaglutide

doi: 10.1016/j.coph.2017.10.005 86 ClemmensenCMllerTDFinanBTschpMHDiMarchiR

( a ) Representative dose-response curves of cAMP assays with GIP (agonist mode) and AMG 133 or hGIPR-Ab/P1 + 50 pM GIP (antagonist mode) in cells expressing human GIPR

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Yes, loperamide (Imodium) can be used occasionally for symptom relief