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And has the (skin) damage already been done

Role of pycnogenol on other skin diseases: There are various mechanisms and biochemical pathways responsible for preventing and curing actions of herbal compounds such as induction of caspase activity, inhibition of angiogenesis and inhibition of the effects of other promoting proteins such as PI3-K, PKC, IKK, Bcl-2, AP-1, STAT3 and MMPs [75]

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