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It is not recommended for people with a personal or family history of medullary thyroid carcinoma or MEN2

L-Carnitine and Acetyl-L-Carnitine: Potential Novel Biomarkers for Major Depressive Disorder Frontiers in Psychiatry (2021), DOI: 10.3389/fpsyt.2021.671151 11

Tirzepatide (Mounjaro or Zepbound) targets both GLP-1 and a second gut hormone called GIP

While the nephroprotective effects of SGLT2i were initially derived from secondary endpoints of CV outcome trials (CVOTs), direct confirmation came from dedicated kidney focused trials: CREDENCE (Perkovic et al NEJM 2019| NephJC Summary), DAPA-CKD (Heerspink et al NEJM 2020| NephJC Summary) and finally EMPAKIDNEY (Herrington et al NEJM 2023| NephJC Summary)

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FAQ: Preventing Muscle Loss on Ozempic and GLP-1s Can Ozempic cause muscle loss in women over 40