Food starts seeming appealing again, though portions remain small
How long tirzepatide takes to work varies, but most people feel something by week 5 or 6
smaller quantities are secreted by the pancreas and the central nervous system
Given their glucose-lowering effects, GLP-1s have become standard of care for type 2 diabetes, supplanting other medication classes such as sulfonylureas.2 In 2023, GLP-1s represented 63% of diabetes spend, up from 38% in 2020.2 While diabetes GLP-1s will continue to account for a greater portion of spend compared to obesity, costs related to GLP-1s prescribed for obesity are expected to grow at a faster rate over the next 3 years
And the cold temperature makes it easier to eat than hot food, which many semaglutide users find more tolerable during the adjustment period
Glucagon-like peptide-1 (GLP-1) signalling in the brain: from neural circuits and metabolism to therapeutics