The metabolic improvements, including better insulin sensitivity and lower androgens, persist for some time after stopping the medication
What they all share is the ability to help patients overcome the physiologic challenges that make weight loss difficult
Common adverse effects include gastrointestinal symptoms, particularly nausea (30-50% of patients), vomiting, diarrhea, and constipation
The half-life of tirzepatide is about 5 days, which means steady state arrives around week 3 to 4 at each dose
If insurance is relying on the fact that not covering it will allow people to buy it out of pocket, as a primary care doctor, I have a lot of concerns about that, Rind said
Instead, they should explain that weight loss stabilization and slowed glycemic improvement are expected parts of chronic disease management that often require reassessment and individualized care planning