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Multiple studies have shown that myostatin (MSTN), a member of the TGF- family, is involved in the development and development of obesity, hyperlipidemia, diabetes, and hypertension (clinical manifestations of metabolic syndrome), and thus may be a potential therapeutic target for metabolic syndrome
GH excess causes sodium and water retention
Newman NJ, Yu-Wai-Man P, Carelli V, Moster ML, Biousse V, Vignal-Clermont C, et al
Am J Physiol-Ren Physiol
These oxygen-derived free radicals can initiate lipid peroxidation within cellular membranes, ultimately leading to renal tubular necrosis (Singh et al