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MTs and cardioprotection in diabetes Several studies have demonstrated that MTs can prevent and inhibit cardiac oxidative stress, protecting against the cardiotoxicity caused by chemotherapeutic agents [132], inhibit pathological changes in the hearts of diabetes patients [133], and protect the cardiac endoplasmic reticulum from stress and apoptosis [134, 135]

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Significantly, metformin has been demonstrated to normalize pulsatile GnRH secretion by reducing circulating insulin levels

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