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While all sham controls share the same goal, removing the active therapeutic element, they differ in how this is achieved and which biases they are designed to minimize

PET has historically been widely used for drug occupancy studies in the brain specifically 15

Indeed, excessive ROS disrupt the BBB integrity, impairing its selective permeability (Hu et al., 2020)

The high protein content and digestive enzymes in spirulina support nutrient absorption

Conclusion Careful investigation of sex differences has the potential to not only fill in the gap for missing research or information for female subjects, which are still often omitted from preclinical studies, but also to more appropriately adjust the doses for both sexes to, for example, increase the effectiveness for body weight loss in men and for women to reduce side effects

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