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Parker HE, Adriaenssens A, Rogers G, Richards P, Koepsell H, Reimann F, and Gribble FM

Semaglutide is a GLP-1 receptor agonist that regulates blood sugar and appetite, while testosterone is a hormone that influences muscle mass, fat distribution, energy, and sex drive

This study thus identifies Kyn accumulation as a potential contributor to mTOR activation and metabolic target of the therapeutic action by NAC in patients with SLE