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Because SAM is required for hundreds of methylation reactions, including those that build creatine and glutathione, low levels of SAM can ripple across nearly every body system

Additionally, decreased antioxidant capacity and vitamin C levels have been observed in the aqueous humor of dogs following extracapsular lens extraction and experimental phacoemulsification, suggesting that these surgical procedures initially induce an OS condition in the eye [206,208]

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Sjoholm A: Impact of glucagon-like peptide-1 on endothelial function

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Irregularities and contamination are common