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Patients with chronic conditions may notice fatigue, brain fog, or worsening disease-specific symptoms in the same timeframe

PMID: 32815278

Our animal models, induced using endothelin-1 (ET-1), reflect clinically relevant cerebral I/R conditions yet may not fully capture the complexity of human pathophysiology, including inter-individual anatomical variation and comorbidities ( in vivo , including their potential off-target effects and clearance pathways

Some reported headaches may reflect impurities or mislabelled doses rather than an intrinsic effect of carnitine

However, more recent studies in mice suggest that beta cells are equipped with other anti-oxidant systems to scav-enge excess ROS, and in particular H 2 O 2