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Although these findings are compelling, they must be interpreted with considerable caution, as observational studies are inherently limited in their ability to establish causality and are susceptible to multiple forms of bias

For example, studies have identified genes such as brain-derived neurotrophic factor (BDNF) and the serotonin transporter gene (SLC6A4) as being closely associated with depression susceptibility [292,293,294]

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This gives people a new option for managing their weight under medical supervision

10.3389/fimmu.2023.1148209 53 MengF.WangK.AoyamaT.GrivennikovS

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