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Shifting by four or five days disrupts the steady state and may increase breakthrough symptoms between doses

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In a mouse model, linaclotide binds to GC-C receptor expressed on the luminal surface of intestinal epithelial cells, which leads to stimulation of cyclic guanosine monophosphate (cGMP) release

Understanding these potential interactions helps patients and healthcare providers develop comprehensive management strategies

doi:10.3390/nu10030349 [4] Andreozzi GM