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The search methodology included terms as oxidative stress, reactive oxygen species, biomarkers, hypertension, endothelial dysfunction, mitochondrial dysfunction, diabetes, -cell damage, vascular dysfunction, hyperglycemia, insulin resistance, vascular complications, diabetic neuropathies, disease progression, antioxidant therapy, clinical trials, and precision redox medicine

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This study is particularly valuable because using an active comparator controls for many confounding factors

Genomic analysis using the Broad Institutes Connectivity Map showed that GHK-Cu can influence the expression of numerous human genes