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Common dosing ranges from 600-1200 mg per dose, typically administered 1-3 times weekly for 4-8 weeks

This signal is potentiated downstream by intracellular cAMP, which is increased by the action of G s protein coupled receptors, further augmenting hormone release (123)

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At the same time, flexibility could help in minimizing GI adverse events

The dose-response data broke down as follows: 1mg dose: 8.7% average weight loss at 48 weeks 4mg dose: 15.2% average weight loss at 48 weeks 8mg dose: 21.1% average weight loss at 48 weeks 12mg dose: 24.2% average weight loss at 48 weeks Placebo: 2.1% average weight loss at 48 weeks The week-by-week progression told an equally compelling story

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