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Long R3 IGF-1 is modified to help increase its potency and stability while still exerting anabolic effects similar to IGF-1 Long stands for the additional 13 amino acids added to the N-terminus of the peptide molecule, while R3 describes the replacement of the 3rd amino acid in the native hormone with arginine

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It helps protect cells against the effects of oxidative stress from dietary and environmental free radicals, and serves as a key factor in detoxification

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As a result, the cellular level of glutathione decreases