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In these cases, carnitine becomes the drug of choice, capable of alleviating the effects of such dysmetabolic states

Certain medical conditionssuch as heart disease, glaucoma, or severe anxietymay increase the risk of adverse effects

Cell Death Disease 14 (3), 205

Its mechanism involves elevating the levels of norepinephrine, a neurotransmitter in the brain for regulating behavior, attention, and response to stress

There is evidence that metformin can cross the bloodbrain barrier and localize in several brain areas ( As with other animal models with metabolic dysfunction, MSG-rats have high parasympathetic and low sympathetic activity

However, there are also limitations