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Similarly, metallic nanoparticles (MNPs) (gold, silver, zinc oxide) are conjugated with phytoextracts like Aloe barbadensis , Leucas aspera , Pyrenacantha grandiflora , and Withania somnifera for wide therapeutic efficacy against microbial infections, ulcerative colitis, cancer, and oxidative stress by facilitating extended drug circulation, intercellular targeting, drug stabilization, and higher delivery [19, 20]

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Including Gi/o protein coupling, cAMP suppression, MAPK pathway activation, -arrestin recruitment, and receptor internalisation and desensitisation

[Abstract]2020 Dec 31:rs.3.rs-100914

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Moreover, patients with the underexcretion phenotype might respond more favorably to uricosuric agents than to XO inhibitors