Originally identified in bacteria, true SspA's present the characteristic GST fold but lacks GST binding activity due to replacement of the catalytic cystine residue (Hansen et al ., Reference Hansen, Gu, Li, Andrykovitch, Waugh, Jin and Ji2005)
There was a progressive decrease of the proportion of patients at target for each 0.5% increase in baseline HbA1c, ranging from 57.8% for HbA1c 7.5% to 20.8% for HbA1c 10% (p for trend 9.0% with no further decrease, whereas for non-insulin drugs the relationship was continuous without any evidence of plateau 5
Psychiatry 17, 290314
Compound heterozygous variants of the NARS2 gene in siblings with developmental delay, epilepsy, and neonatal diabetes syndrome
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Nat Med 31(8):26402646