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The theoretical rationale for combination therapy rests on targeting multiple neurochemical systems: GLP-1 controls homeostatic appetite, while naltrexone modulates reward-based eating behavior

What to Expect with Retatrutide Retatrutide is administered as a once-weekly subcutaneous injection

The appetite-suppressing effects can lead individuals to consume too little, missing essential nutrients

Screening for additional comorbidities such as cardiovascular disease and diabetes is essential because retatrutide has the potential to impact glucose metabolism and cardiovascular health

Moreover, the data used for this model did not extend beyond 52 weeks, necessitating extrapolation

PMID: 2890903