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In a healthy, optimally functioning body, glutathione acts as the primary defense mechanism against reactive oxygen species (ROS), actively neutralizing free radicals before they can cause irreversible damage to cellular membranes, functional proteins, and mitochondrial DNA

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P-glycoprotein (P-gp) greatly impacts substrate drug disposition, so much so that regulatory agencies recommend ascertaining the P-gp status of active pharmaceutical ingredients (APIs) intended for human use