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Comment: Many commenters had concerns about the proposal to exclude ACOs that fall below 5,000 assigned beneficiaries in any benchmark year from being eligible to leverage existing policies that provide certain low revenue ACOs participating in the BASIC track with increased opportunities to share in savings, and urged CMS to reconsider the proposal

Incidence and distribution of argininosuccinate synthetase deficiency in human cancers: a method for identifying cancers sensitive to arginine deprivation

(1991) documented that IV infusion of 2 g/m^2 raised plasma glutathione from 17.5 umol/L to 823 umol/L -- a roughly 47-fold increase -- with a half-life of approximately 14 minutes (Aebi et al., 1991)