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In September 2025, the FDA and the Department of Health and Human Services (HHS) launched an enforcement initiative targeting misleading advertising in the compounded drug space

Retatrutide Side Effects Are Similar to Existing Diabetes and Obesity Injectables The most common side effects for retatrutide were: Nausea (16 to 27 percent of participants, depending on dosage, compared with 3.7 percent of those taking a placebo) Diarrhea (19 to 23 percent, compared with 5 percent taking a placebo) Vomiting (16 to 18 percent, compared with 2 percent taking a placebo) Nerve issues (2 to 4 percent, compared with none taking a placebo) Between 2 and 5 percent of participants on retatrutide stopped taking it before the trial ended, with a greater risk of stopping among those who took the highest dose

Some research suggests it may have potential benefits for wound healing and tissue repair

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Some patients still use oral forms for maintenance