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The repetitive triggering of C-fibers during migraine attacks and the resultant stimulation of CGRP-mediated pain pathways keep the TVS in a state of heightened sensitivity, thus contributing to the progression of migraine into a chronic condition (10, 33)

doi: 10.1210/jc.2008-0519 40 MeltzerLJMontgomery-DownsHEInsanaSPWalshCM

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In addition, there is a reduction in the replenishment of docked pools from the reserve pool [29]

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