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Similarly, understanding alcohol interactions with other GLP-1 agonists provides broader context for this concern

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In obesity, the gut microbiota is dysbiotic, and this dysbiosis is associated with blunted endogenous GLP-1 secretion, partly through downregulation of GLP-1R and nNOS expression in the enteric nervous system (Inagaki & Yamane, 2017)

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It is a naturally occurring peptide found in human plasma, saliva, and urine