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The final OTU table was rarefied into 61,600 reads/sample

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Management generally involves levothyroxine replacement therapy, complemented in some cases by dietary optimization and micronutrient supplementation

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In addition, the analgesic effect of melatonin is mediated through activation of supraspinal sites, inhibition of spinal nociception, and modulation of various neurobiological systems, including GABAergic, opioid, and glutamatergic systems [65]

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